cellxgene_census.experimental.ml.huggingface.GeneformerTokenizer

class cellxgene_census.experimental.ml.huggingface.GeneformerTokenizer(experiment: Experiment, *, obs_column_names: Sequence[str] | None = None, obs_attributes: Sequence[str] | None = None, max_input_tokens: int = 2048, token_dictionary_file: str = '', gene_median_file: str = '', **kwargs: Any)

Generate a Hugging Face Dataset containing Geneformer token sequences for each cell in CELLxGENE Census ExperimentAxisQuery results (human).

This class requires the Geneformer package to be installed separately with: pip install git+https://huggingface.co/ctheodoris/Geneformer@8df5dc1

Example usage:

``` import cellxgene_census import tiledbsoma from cellxgene_census.experimental.ml.huggingface import GeneformerTokenizer

with cellxgene_census.open_soma(census_version=”latest”) as census:

with GeneformerTokenizer(

census[“census_data”][“homo_sapiens”], # set obs_query to define some subset of Census cells: obs_query=tiledbsoma.AxisQuery(value_filter=”is_primary_data == True and tissue_general == ‘tongue’”), obs_column_names=(

“soma_joinid”, “cell_type_ontology_term_id”,

),

) as tokenizer:

dataset = tokenizer.build()

```

Dataset item contents: - input_ids: Geneformer token sequence for the cell - length: Length of the token sequence - and the specified obs_column_names (cell metadata from the experiment obs dataframe)

__init__(experiment: Experiment, *, obs_column_names: Sequence[str] | None = None, obs_attributes: Sequence[str] | None = None, max_input_tokens: int = 2048, token_dictionary_file: str = '', gene_median_file: str = '', **kwargs: Any) → None

• experiment: Census Experiment to query

• obs_query: obs AxisQuery defining the set of Census cells to process (default all)

• obs_column_names: obs dataframe columns (cell metadata) to propagate into attributes

  of each Dataset item

• max_input_tokens: maximum length of Geneformer input token sequence (default 2048)

• token_dictionary_file, gene_median_file: pickle files supplying the mapping of Ensembl human gene IDs onto Geneformer token numbers and median expression values. By default, these will be loaded from the Geneformer package.

Methods

X(layer_name, *[, batch_size, partitions, ...])	Returns an X layer as a sparse read.
__init__(experiment, *[, obs_column_names, ...])	experiment: Census Experiment to query
build([from_generator_kwargs])	Build the dataset from query results.
cell_item(cell_joinid, cell_Xrow)	Given the expression vector for one cell, compute the Dataset item providing the Geneformer inputs (token sequence and metadata).
close()	Releases resources associated with this query.
obs(*[, column_names, batch_size, ...])	Returns obs as an Arrow table iterator.
obs_joinids()	Returns obs soma_joinids as an Arrow array.
obsm(layer)	Returns an obsm layer as a sparse read.
obsp(layer)	Returns an obsp layer as a sparse read.
to_anndata(X_name, *[, column_names, ...])	Executes the query and return result as an AnnData in-memory object.
var(*[, column_names, batch_size, ...])	Returns var as an Arrow table iterator.
var_joinids()	Returns var soma_joinids as an Arrow array.
varm(layer)	Returns a varm layer as a sparse read.
varp(layer)	Returns a varp layer as a sparse read.

Attributes

indexer	A soma_joinid indexer for both obs and var axes.
n_obs	The number of obs axis query results.
n_vars	The number of var axis query results.
obs_column_names
max_input_tokens
model_gene_ids
model_gene_tokens
model_gene_medians