A native port of the ExpressionMatrix2 software to MacOS is not available. 
The easiest way to use ExpressionMatrix2 software on MacOS is via
Docker.
A Docker image for the ExpressionMatrix2 software is available in GitHub repository  
iosonofabio/organic-box-factory.
Detailed instruction on how to use it are available 
here.
Alternatively, you can use VirtualBox
to create a virtual machine running Ubuntu 16, and use the ExpressionMatrix2 software
inside the virtual machine.